Modeling hypoglycemia risk in T1D
The goal of this project is to build mixed effects machine learning models to study the effect of different forms of exercise on hypoglycemia risk during and up to 24 hours after physical activity.
Welcome!
Thank you for visiting my research website. I am currently an Assistant Professor at OHSU working in the Artificial Intelligence for Medical Systems (AIMS) Lab. Prior to joining the BME Department at OHSU, I was a Senior Imaging Scientist at Intel Corporation. I obtained my Ph.D. in Electrical Engineering from the University of Texas at San Antonio where I worked with Dr. Sos S. Agaian.
Current research interests
Computational biology ▪ artificial intelligence (AI) ▪ data-driven modeling ▪ physiology-guided machine learning ▪ biomedical image analysis ▪ diabetes technologies ▪ computer-aided diagnosis ▪ computer vision.
News
| ATTD Conference 03/2024 |
Valentina, Leah, and Peter present the work of the AIMS Lab on (1) physiology-guided AI digital twins in type 1 diabetes, (2) AI-based inference of meal insulin dosing behavior in people with type 1 diabetes, and (3) automated meal detection for closed loop at the 17th ATTD Conference in Florence, Italy. |
| New paper 11/2023 |
P. G. Jacobs et al., “Artificial intelligence and machine learning for improving glycemic control in diabetes: best practices, pitfalls and opportunities,” IEEE Rev. Biomed. Eng., pp. 1–19, 2023, doi: 10.1109/RBME.2023.3331297. |
| The DiabetesMine Innovation Summit 11/2023 |
Clara presents the work of the AIMS Lab on automated meal detection for closed loop in San Diego, CA. |
| Virtual Diabetes Technology Meeting 11/2023 |
Clara presents the work of the AIMS Lab on uncertainty-aware nocturnal hypoglycemia prediction. |
| New paper 10/2023 |
C. Mosquera-Lopez et al., “Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections,” Journal of the American Medical Informatics Association, p. ocad196, Oct. 2023, doi: 10.1093/jamia/ocad196. |
| New paper 09/2023 |
T. Kushner, C. Mosquera-Lopez, A. Hildebrand, M. H. Cameron, and P. G. Jacobs, “Risky movement: Assessing fall risk in people with multiple sclerosis with wearable sensors and beacon-based smart-home monitoring,” Multiple Sclerosis and Related Disorders, vol. 79, p. 105019, Nov. 2023, doi: 10.1016/j.msard.2023.105019. |
| New paper 03/2023 |
C. Mosquera-Lopez et al., “Enabling fully automated insulin delivery through meal detection and size estimation using Artificial Intelligence,” npj Digit. Med., vol. 6, no. 1, Art. no. 1, Mar. 2023, doi: 10.1038/s41746-023-00783-1. |
| New paper (Recognized as paper of the month by OHSU School of Medicine) 02/2023 |
C. Mosquera-Lopez, K. L. Ramsey, V. Roquemen-Echeverri, and P. G. Jacobs, “Modeling risk of hypoglycemia during and following physical activity in people with type 1 diabetes using explainable mixed-effects machine learning,” Computers in Biology and Medicine, vol. 155, p. 106670, Mar. 2023, doi: 10.1016/j.compbiomed.2023.106670. |
| New QSB award 02/2023 |
The BE-In-AIMS internship program will be supported by the 2023 OHSU Quantitative and Systems Biology (QSB) award; with Dr. Jacobs |
| New award 12/2022 |
Valentina Roquemen-Echeverri was awarded a Professional Development Scholarship from Women in Science Portland. Congratulations! |
| Colombian Endocrinology Association (ACE) DITEC 1.0 virtual course 10/2022 |
Clara gave a talk on AI and its applications in diabetes management hosted by Dr. Alex Ramirez-Rincon |
| New JDRF award 09/2022 |
"Development of an open-source AI-based digital twin generator for replicating personalized glucose dynamics in people with type 1 and type 2 diabetes"; with AIMS Lab team |
| New paper 08/2022 |
J. R. Castle et al., “Assessment of a Decision Support System for Adults with Type 1 Diabetes on Multiple Daily Insulin Injections,” Diabetes Technology & Therapeutics, Aug. 2022, doi: 10.1089/dia.2022.0252. |
| ATTD Conference 04/2022 |
Clara presents the work of the AIMS Lab on (1) automated meal detection for closed loop and (2) hypoglycemia risk during and following physical activity at the 15th ATTD Conference in Barcelona, Spain. |
| New student 03/2022 |
Valentina Roquemen-Echeverri joins the AIMS Lab. Welcome Valentina! |
| New paper 03/2022 |
N. S. Tyler, C. Mosquera-Lopez, G. M. Young, J. El Youssef, J. R. Castle, and P. G. Jacobs, “Quantifying the impact of physical activity on future glucose trends using machine learning,” iScience, vol. 25, no. 3, p. 103888, Mar. 2022, doi: 10.1016/j.isci.2022.103888. |
| New OHSU REI + BME award 11/2021 |
"Bias Equity and Inclusion in Artificial Intelligence for Medical Systems Internship (BE-In-AIMS)"; with Dr. Jacobs |
| Oregon Bioengineering Symp. 11/2021 |
Clara gives a presentation on some of the work in the AIMS Lab. |
| New OCTRI IDEA Gap award |
"Development of a Novel Smart-Phone-Based Stethoscope Device that uses Machine Learning to Detect, Diagnose, and Determine the Severity of Cardiac and Pulmonary Disease"; with Dr. Schulman, Dr. Heitner, and Dr. Jacobs |
| New NIH/NIDDK R21 award 09/2021 |
"Development and Evaluation of Personalized Explainable Machine Learning Models to Predict and Prevent Nocturnal Hypoglycemia in Type 1 Diabetes"; with AIMS Lab team |
Research projects
As a research faculty in the AIMS Lab, I am involved in multiple research projects in the general field of computational biology. Below are selected projects in which I am a principal investigator (PI or co-PI).
Explainable AI for prediction and prevention of nocturnal hypoglycemia in T1D
The goal of this project is to develop and evaluate (in a clinical trial) the effect of a personalized machine-learning-based recommender system that analyzes glucose profile and physical activity to predict at bedtime the likelihood of overnight hypoglycemia.
Bias Equity and Inclusion in Artificial Intelligence for Medical Systems Internship (BE-In-AIMS)
With Co-PI Dr. Jacobs
BE-In-AIMS creates opportunities for students from diverse backgrounds or underrepresented groups to participate in world-class research at the intersection of AI and medical systems design and development. The specific focus of this program is to explore how racial, gender, or other bias impacts the performance of machine learning algorithms.
AI-powered diabetes simulation platform
The goal of this project is to build an open-source AI-based digital twin generator for replicating personalized glucose dynamics in people with type 1 and type 2 diabetes.
Device and algorithms for structural heart disease diagnosis (Telluscope)
With Tellunostics LLC
The goal of this project is to build a new AI-powered cardiac auscultation device for improved structural heart murmur diagnosis.
Students
Valentina Roquemen-Echeverri, BSc
PhD student, BME|OHSU, Co-advised with Dr. Jacobs
Spring 2022 ▸
Valentina holds a BSc in Physics from the Universidad de Antioquia (COL). Her research focuses on physiology-guided AI and its applications in computational cardiology and diabetes technologies. Learn more
Clara Escorihuela-Altaba, MSc
PhD student, University of Bern, Co-advised with Dr. Garcia-Tirado
Spring 2023 ▸
Clara holds a BSc in Biomedical Engineering from the University of Barcelona (ESP) and an MSc in Medical Engineering (Informatics) from the KTH Royal Institute of Technology (SWE). Her research involves combining mathematical physiological models with artificial intelligence to develop innovative solutions that can help individuals with diabetes manage their condition more effectively. GitHub / Learn more
Interns/Volunteers
Kyle Chen: Fall 2023
Jenny Wang: Summer 2023
Mary Loeb: Summer 2023
Tomas Londono-Murillo: Fall 2022 ▸ Fall 2023
Dylan Jacobs: Summer 2021,2022
Clara Escorihuela-Altaba, MSc: Summer 2022
Jenny Wang: Summer 2023
Mary Loeb: Summer 2023
Tomas Londono-Murillo: Fall 2022 ▸ Fall 2023
Dylan Jacobs: Summer 2021,2022
Clara Escorihuela-Altaba, MSc: Summer 2022
Collaborations
Below is a list of collaborators and researchers I work with, who are not members of the AIMS Lab.
| Dr. Melanie B. Gillingham | Molecular and Medical Genetics, OHSU (USA) |
| Dr. Jhonattan Cordoba-Ramirez | Dept. of Electrical Eng., Federal University of Minas Gerais - UFMG (Brazil) |
| Dr. Jorge Mahecha-Gomez | Institute of Physics, Universidad de Antioquia (Colombia) |
| Dr. Edison Montoya | Institute of Mathematics, Universidad de Antioquia (Colombia) |
| Dr. Taisa Kushner | Galois, Inc. (USA) |
| Dr. Jose Garcia-Tirado | University Clinic of Diabetes, Endocrinology, and Metabolism, University of Bern (Switzerland) |
Teaching
| Fall 2021, Winter 2022, Spring 2022, Summer 2022, Fall 2022, Winter 2023, Fall 2023 | OHSU | BME 610NN/605 | Machine Learning/Mathematical Modeling Group, with Dr. Jacobs |
| Spring 2023 | OHSU | BME 680 | Digital Signal Processing, with Dr. Jacobs |
Selected publications
T1D: type 1 diabetes | MS: multiple sclerosis | BioSen: biosensors | PCa: prostate cancer | DS: data science
[T1D]
C. Mosquera-Lopez et al., “Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections,” Journal of the American Medical Informatics Association, p. ocad196, Oct. 2023, doi: 10.1093/jamia/ocad196.
[MS]
T. Kushner, C. Mosquera-Lopez, A. Hildebrand, M. H. Cameron, and P. G. Jacobs, “Risky movement: Assessing fall risk in people with multiple sclerosis with wearable sensors and beacon-based smart-home monitoring,” Multiple Sclerosis and Related Disorders, vol. 79, p. 105019, Nov. 2023, doi: 10.1016/j.msard.2023.105019.
[DS]
E. N. Erickson, N. Gotlieb, L. M. Pereira, L. Myatt, C. Mosquera-Lopez, and P. G. Jacobs, “Predicting labor onset relative to the estimated date of delivery using smart ring physiological data,” npj Digit. Med., vol. 6, no. 1, Art. no. 1, Aug. 2023, doi: 10.1038/s41746-023-00902-y.
[T1D]
P. G. Jacobs et al., “Integrating metabolic expenditure information from wearable fitness sensors into an AI-augmented automated insulin delivery system: a randomised clinical trial,” The Lancet Digital Health, p. S2589750023001127, Aug. 2023, doi: 10.1016/S2589-7500(23)00112-7.
[T1D]
C. Mosquera-Lopez et al., “Enabling fully automated insulin delivery through meal detection and size estimation using Artificial Intelligence,” npj Digit. Med., vol. 6, no. 1, Art. no. 1, Mar. 2023, doi: 10.1038/s41746-023-00783-1.
[T1D]
C. Mosquera-Lopez, K. L. Ramsey, V. Roquemen-Echeverri, and P. G. Jacobs, “Modeling risk of hypoglycemia during and following physical activity in people with type 1 diabetes using explainable mixed-effects machine learning,” Computers in Biology and Medicine, vol. 155, p. 106670, Mar. 2023, doi: 10.1016/j.compbiomed.2023.106670.
[T1D]
N. S. Tyler, C. Mosquera-Lopez, G. M. Young, J. El Youssef, J. R. Castle, and P. G. Jacobs, “Quantifying the impact of physical activity on future glucose trends using machine learning,” iScience, vol. 25, no. 3, p. 103888, Mar. 2022, doi: 10.1016/j.isci.2022.103888.
[T1D]
C. Mosquera-Lopez and P. G. Jacobs, “Incorporating Glucose Variability into Glucose Forecasting Accuracy Assessment Using the New Glucose Variability Impact Index and the Prediction Consistency Index: An LSTM Case Example,” J Diabetes Sci Technol, vol. 16, no. 1, pp. 7–18, Jan. 2022, doi: 10.1177/19322968211042621.
[MS]
C. Mosquera-Lopez et al., “Automated Detection of Real-World Falls: Modeled From People With Multiple Sclerosis,” IEEE J. Biomed. Health Inform., vol. 25, no. 6, pp. 1975–1984, Jun. 2021, doi: 10.1109/JBHI.2020.3041035.
[T1D]
C. Mosquera-Lopez et al., “Predicting and Preventing Nocturnal Hypoglycemia in Type 1 Diabetes Using Big Data Analytics and Decision Theoretic Analysis,” Diabetes Technology & Therapeutics, vol. 22, no. 11, pp. 801–811, Nov. 2020, doi: 10.1089/dia.2019.0458.
[BioSen]
P. G. Jacobs et al., “Measuring glucose at the site of insulin delivery with a redox-mediated sensor,” Biosensors and Bioelectronics, vol. 165, p. 112221, Oct. 2020, doi: 10.1016/j.bios.2020.112221.
[T1D]
N. S. Tyler et al., “An artificial intelligence decision support system for the management of type 1 diabetes,” Nat Metab, vol. 2, no. 7, pp. 612–619, Jul. 2020, doi: 10.1038/s42255-020-0212-y.
[Sleep]
C. Mosquera-Lopez et al., “Design and Evaluation of a Non-Contact Bed-Mounted Sensing Device for Automated In-Home Detection of Obstructive Sleep Apnea: A Pilot Study,” Biosensors, vol. 9, no. 3, p. 90, Jul. 2019, doi: 10.3390/bios9030090.
[PCa]
C. Mosquera-Lopez, S. Agaian, A. Velez-Hoyos, and I. Thompson, “Computer-Aided Prostate Cancer Diagnosis From Digitized Histopathology: A Review on Texture-Based Systems,” IEEE Rev Biomed Eng, vol. 8, pp. 98–113, 2015, doi: 10.1109/RBME.2014.2340401.